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IL-10 Polyclonal Antibody

CAT: 0965-JOT-AP04429-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04429-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-10 encoded by IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
CAS Number
9007-83-4
Synonyms
IL10; IL 10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL10. AA range:71-120
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
20517
Antibody Type
Primary antibody
Isotype
IgG

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