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GluR-Delta2 Polyclonal Antibody

CAT: 0965-JOT-AP03602-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP03602-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
CAS Number
9007-83-4
Synonyms
GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
Clonality
Polyclonal
Applications
WB, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
113431
Antibody Type
Primary antibody
Isotype
IgG

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