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Cyclin D3 Polyclonal Antibody

CAT: 0965-JOT-AP02352-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02352-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by CCND3 (cyclin D3) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for CCND3.
CAS Number
9007-83-4
Synonyms
CCND3; G1/S-specific cyclin-D3
Host
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human Cyclin D3. AA range:243-292
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
32520
Antibody Type
Primary antibody
Isotype
IgG