Products for Research Use Only
RegisterLogin

Chk2 Polyclonal Antibody

CAT: 0965-JOT-AP01767-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0965-JOT-AP01767-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. Checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in CHEK2 have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for CHEK2.
CAS Number
9007-83-4
Synonyms
CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human CHEK2. AA range:486-535
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
60915
Antibody Type
Primary antibody
Isotype
IgG

Related Products

CatalogName
JOT-AP07672-01Chk2(Phospho Ser516) Polyclonal Antibody
JOT-AP07673-01Chk2(Phospho Thr383) Polyclonal Antibody
JOT-AP14958-01Chk2(Phospho Thr387) Polyclonal Antibody
JOT-AP01742-01Chk2(Phospho Thr68) Polyclonal Antibody
JOT-MCA0339-01Chk2 Monoclonal Antibody
JOT-AP07757-01Chk2(Phospho-Ser19) Rabbit Polyclonal Antibody
JOT-AP07748-01Chk2(Phospho Thr432) Rabbit Polyclonal Antibody
JOT-EK2817Mo-01Mouse Phospho-Chk2 (T68), pChk2 ELISA KIT
JOT-EK7716Hu-01Human Phospho-Chk2 (T68), pChk2 ELISA KIT
JOT-AP01763-01Chk1 Polyclonal Antibody

Alternative Products

CatalogName
MBS8521887-01Chk2 Polyclonal Antibody

Popular Products