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Caspase-14 Polyclonal Antibody

CAT: 0965-JOT-AP01197-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP01197-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 14 has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of caspase 14 may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
CAS Number
9007-83-4
Synonyms
CASP14; Caspase-14; CASP-14
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from Caspase-14 . at AA range: 110-190
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
27680
Antibody Type
Primary antibody
Isotype
IgG