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BLNK Polyclonal Antibody

CAT: 0965-JOT-AP00909-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00909-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein (B-cell linker)has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for BLNK.
CAS Number
9007-83-4
Synonyms
BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-
Host
Rabbit
Reactivity
Human;Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human BLNK. AA range:62-111
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
50466
Antibody Type
Primary antibody
Isotype
IgG

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