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ATF-2 Polyclonal Antibody

CAT: 0965-JOT-AP00699-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00699-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATF2 encodes a transcription factor (activating transcription factor 2) that is a member of the leucine zipper family of DNA binding proteins. Activating transcription factor 2 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Activating transcription factor 2 binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Activating transcription factor 2 may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this ATF2.
CAS Number
9007-83-4
Synonyms
ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CRE
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ATF2. AA range:29-78
Clonality
Polyclonal
Applications
WB, IHC-p, IP, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
52277
Antibody Type
Primary antibody
Isotype
IgG

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