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11 Beta-HSD1 Polyclonal Antibody

CAT: 0965-JOT-AP00001-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00001-01Size:20 µL
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Background
Hydroxysteroid 11-beta dehydrogenase 1 encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in HSD11B1 has been associated with obesity and insulin resistance in children. Mutations in HSD11B1 and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
CAS Number
9007-83-4
Synonyms
HSD11B1; HSD11; HSD11L; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HSD11B1. AA range:1-50
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
32401
Antibody Type
Primary antibody
Isotype
IgG

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