(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 (TFA)

(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 (TFA)

• CAS Number: 2417370-48-8
• UNSPSC Description: (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based ligand and 3-unit PEG linker used in PROTAC technology[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-3-methylbutanyl-acetate-methanesulfonothioate-peg3-nh2-tfa.html
• Smiles: O=C(N(C[C@@H]1OC(OC(C)C(C)S[S](C)(=O)=O)=O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCN)=O.OC(C(F)(F)F)=O
• Molecular Weight: 944.07
• References & Citations: [1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.
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