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Isograndifoliol

CAT: 0804-HY-N10781Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10781Size:1 Each
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Description
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].
CAS Number
1445475-53-5
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/isograndifoliol.html
Solubility
10 mM in DMSO
Smiles
CC1=CC2=C(C=C(C1=O)O)[C@](CCCC3(C)C)(CO)[C@H]3CC2
Molecular Formula
C19H26O3
Molecular Weight
302.41
References & Citations
[1]Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21 (12) :4475. |[2]Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348. |[3]Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11 (2) :159-61.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE; BChE

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CatalogName
MBS5815082Isograndifoliol

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