Human CLDN18.2 Protein

• Background:

  Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

• Structure Composition:

  PBS, pH7.4

• Swiss Prot:

  P56856-2

• Reactivity:

  293F

• Type of Marker:

  Line 1:293F transfected IgG2-Claudin 18.2-hFc cell supernatant (500ng)

• Applications:

  Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies

• Dilution:

  Recombinant protein from a target gene encoding the extracellular domain loop 1 of Homo sapiens claudin 18 (CLDN18), transcript variant 2 (NM_001002026), with a hFC tag.

• Purity:

  The protein was purified from 293F and the purity is > 95% (by SDS-PAGE) .

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  AA Asp 28 - Arg 80 (Accession # P56856-2)

• Host or Source:

  Human

• Control Type:

  Line 1:293F transfected IgG2-Claudin 18.2-hFc cell supernatant (4μg)