EIF2S1 Recombinant Rabbit mAb

• Background :

  The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]) .[supplied by OMIM, Feb 2010]

• CAS Number :

  9000-83-3

• Structure Composition :

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative :

  EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha

• Swiss Prot :

  P05198, Q6ZWX6, P68101

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide of human EIF2S1

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC, IP

• Purity :

  Affinity Purification

• Modification :

  Unmodification

• Molecular Weight :

  36 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot analysis of extracts from MCF-7, HepG2 cells at 1:1000.

• Host or Source :

  Rabbit