GRID2 Recombinant Rabbit mAb

CAT: 0384-BS48848-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS48848-01Size:50 µL
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Background
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
GluD2; SCAR18
Swiss Prot
O43424
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human GRID2
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:2000
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
113 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of extracts from Mouse brain tissue at 1:1000.
Host or Source
Rabbit

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