CYP2C19 Recombinant Rabbit mAb

• Background:

  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19

• Swiss Prot:

  P33261

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human CYP2C19

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  56 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of extracts from Mouse liver tissue at 1:1000.

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3