Pyrin Recombinant Rabbit mAb

• Background:

  Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation.

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  FMF; pyrin; TRIM20

• Swiss Prot:

  Q9JJ26

• Reactivity:

  Mouse

• Immunogen:

  Recombinant protein of mouse Pyrin

• Conjugation:

  Unconjugated

• Applications:

  WB, IP

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  100 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3