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IREB2 Recombinant Rabbit mAb

CAT: 0384-BS47979-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS47979-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD) . Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
ACO3; IRP2; IRP2AD; IRE-BP2; IRE-BP 2
Swiss Prot
P48200
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human IREB2
Conjugation
Unconjugated
Applications
WB, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
105 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Host or Source
Rabbit

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