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MLH1 Recombinant Rabbit mAb

CAT: 0384-BS47225-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS47225-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . [provided by RefSeq, Aug 2017]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
FCC2; COCA2; HNPCC; hMLH1; HNPCC2
Swiss Prot
P40692
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human MLH1
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC, IP
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
85 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of MLH1 in K562, C6,3T3, Hela cell lysates using MLH1 antibody (1:1000 diluted) .
Host or Source
Rabbit

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