MGluR1a Recombinant Rabbit mAb

• Background:

  This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85

• Swiss Prot:

  Q13255

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human mGluR1a

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:1000

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  125,250 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of extracts from Mouse brain tissue using db13137 at 1:1000.

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3