TAB3 Recombinant Rabbit mAb

• Background:

  The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  NAP1; MAP3K7IP3

• Swiss Prot:

  Q8N5C8

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide of human TAB3

• Conjugation:

  Unconjugated

• Applications:

  WB, ICC/IF

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  82 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of extracts from Caco-2 cells using db13239 at 1:1000.

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3