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APC Recombinant Rabbit mAb

CAT: 0384-BS45585-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS45585-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
Swiss Prot
P25054
Reactivity
Human, Rat
Immunogen
A synthetic peptide of human APC
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC, IP
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of APC in Hela, A549, HL-60, U2OS cell lysates using APC antibody (1:1000 diluted) .
Host or Source
Rabbit

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