Securin Recombinant Rabbit mAb

• Background:

  The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  EAP1; PTTG; HPTTG; TUTR1

• Swiss Prot:

  O95997

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide of human Securin

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, FC, IP

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  25 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot detection of Securin in K562,3T3, Hela cell lysates using Securin antibody (1:1000 diluted) .

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3