Phospho-Cdc6 (Ser54) Recombinant Rabbit mAb

• Background:

  The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  CDC18L; HsCDC6; MGORS5; HsCDC18

• Swiss Prot:

  Q99741

• Reactivity:

  Human

• Immunogen:

  A synthetic phosphopeptide corresponding to residues surrounding Ser54 of human Cdc6

• Conjugation:

  Unconjugated

• Applications:

  WB, ICC/IF

• Purity:

  Affinity Purification

• Modification:

  Phosphorylated

• Molecular Weight:

  63 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3