Phospho-CBL (Ser669) Recombinant Rabbit mAb

• Background:

  This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  CBL2; NSLL; C-CBL; RNF55; FRA11B

• Swiss Prot:

  P22681

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic phosphopeptide corresponding to residues surrounding Ser669 of human CBL

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:1000

• Purity:

  Affinity Purification

• Modification:

  Phosphorylated

• Molecular Weight:

  120 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot detection of Phospho-CBL (Ser669) in K562 cell lysates using Phospho-CBL (Ser669) antibody (1:1000 diluted) .

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3