Phospho-p53 (Ser392) Recombinant Rabbit mAb

• Background:

  This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277) . [provided by RefSeq, Dec 2016]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  P53; BCC7; LFS1; TRP53

• Swiss Prot:

  P04637

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic phosphopeptide corresponding to residues surrounding Ser392 of human p53

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, IP

• Purity:

  Affinity Purification

• Modification:

  Phosphorylated

• Molecular Weight:

  53 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of extracts from HEK293, A431 cells using BS43076 at 1: 1000.

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3