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METTL4 polyclonal antibody

CAT: 0384-BS71800-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS71800-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
N (6-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N (6-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A (m on internal positions of U2 small nuclear RNA (snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation. Internal m6A (m methylation of snRNAs regulates RNA splicing. Also able to act as a N (6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N (6-methyladenosine. The existence of N (6-methyladenosine (m6A on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N (6-adenine-specific DNA methyltransferase activity of METTL4 in vivo. Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA copy number by mediating mtDNA N (6-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending. N (6-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
METTL4; HsT661
Swiss Prot
Q8N3J2
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human METTL4 (NP_073751.3) .
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB,1:1000 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
54kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Polyclonal Antibodies
Host or Source
Rabbit

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