CD22 polyclonal antibody

CAT: 0384-BS7860-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS7860-01Size:50 µL
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Background
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or Blymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CD22; SIGLEC-2; SIGLEC2
Swiss Prot
P20273
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CD22 (NP_001762.2) .
Conjugation
Unconjugated
Applications
WB, IF/ICC
Dilution
WB,1:500 - 1:2000|IF/ICC,1:10 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
140KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Polyclonal Antibodies
Host or Source
Rabbit

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