PTPN2 polyclonal antibody

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  PTPT; Tyrosine-protein phosphatase non-receptor type 2; T-cell protein-tyrosine phosphatase; TCPTP

• Swiss Prot:

  P17706

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human PTPN2 (P17706) .

• Conjugation:

  Unconjugated

• Applications:

  WB, IF/ICC

• Dilution:

  WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  48kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  PTPN2 polyclonal antibody detects endogenous levels of PTPN2 protein.

• Applications Notes:

  Western blot analysis of PTPN2 expression in Jurkat (A), K562 (B) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4