CPEB3 polyclonal antibody

• Background:

  Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE, a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity. Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity. When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity.

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  CPEB3

• Swiss Prot:

  Q8NE35

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human CPEB3 (NP_055727.3) .

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, IF/ICC

• Dilution:

  WB,1:200 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  75kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Polyclonal Antibodies

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4