PEG10 monoclonal antibody

• Background:

  Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity) . May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein; EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3

• Swiss Prot:

  Q86TG7

• Reactivity:

  Human

• Immunogen:

  Recombinant full length Human PEG10.

• Conjugation:

  Unconjugated

• Applications:

  WB IP

• Dilution:

  WB: 1:1000 IP: 1:50~1:200

• Purity:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  Predicted band size:55KDa Observed band size:55KDa/95KDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins

• Applications Notes:

  Western blot detection of PEG10 in Hela cell lysates using PEG10 antibody (1:1000 diluted) .

• Host or Source:

  Mouse IgG1

• CAS Number:

  9007-83-4