GLUL polyclonal antibody

CAT: 0384-BZ00935-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BZ00935-01Size:50 µL
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Background
Glutamine synthetase (GI Syn) forms a homooctamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase; GLNS; Gl Syn
Swiss Prot
P15104
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Glutamine Synthetase.
Conjugation
Unconjugated
Related Pathways
Glutamine Metabolism
Applications
WB IHC IP FC
Dilution
WB: 1:500-1:2000 IHC: 1:50-1:200 IP/FC: 1:50
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 49 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Glutamine Synthetase Antibody detects endogenous levels of total Glutamine Synthetase.
Applications Notes
Western blot analysis of Glutamine Synthetase expression in (1) Jurkat cell lysate; (2) HeLa cell lysate.
Host or Source
Rabbit

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