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NIPP1 polyclonal antibody

CAT: 0384-BS8541-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8541-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (fork-head associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed α, β and γ due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The γ isoform is believed to be a magnesium dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The α and β isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accomplished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8; Activator of RNA decay; ARD-1; PPP1R8; ARD1
Swiss Prot
Q12972
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human NIPP1.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:2000 IHC/IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NIPP1 polyclonal antibody detects endogenous levels of NIPP1 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using PPP1R8 antibody.
Host or Source
Rabbit

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