ETV7 polyclonal antibody

Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain which contains a sequence related to the SV40 large T antigen nuclear localization sequence. This conserved carboxy domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. TEL2, also known as ETV7 (ets variant gene 7), TREF or TELB, is a 341 amino acid nuclear protein that contains one PNT domain and one Ets DNA-binding domain. Expressed in hematopoietic tissue, TEL2 belongs to the Ets family and functions as a transcriptional repressor that binds to the DNA sequence 5'-CCGGAAGT-3'. Defects in the gene encoding TEL2 are associated with B-cell malignancies, suggesting an important role for TEL2 in carcinogenesis. Seven isoforms (designated A-G) of TEL2 exist due to alternative splicing events.

9007-83-4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Transcription factor ETV7; ETS translocation variant 7; ETS-related protein Tel2; Tel-related Ets factor; Transcription factor Tel-2; ETV7; TEL2; TELB; TREF

Q9Y603

Human, Mouse, Rat

Recombinant full length Human ETV7.

Unconjugated

WB

WB 1:500 - 1:2000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Unmodification

~ 39 kDa

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.

ETV7 polyclonal antibody detects endogenous levels of ETV7 protein.

WesternBlot (WB) analysis of ETV7 polyclonal antibody