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UBE2V1 polyclonal antibody

CAT: 0384-BS8126-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8126-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Uev1A, also designated Uev1, UBE2V1 for Ubiquitin-conjugating enzyme E2 variant 1 and CROC1, shows sequence similarity to other ubiquitin-conjugating enzymes, but lacks the conserved cysteine residue critical for their catalytic activity . Therefore, Uev1A does not have ubiquitin-conjugating activity in vitro . However, constitutive expression of exogenous Uev1A in colon carcinoma cells inhibits their capacity to differentiate upon confluence. Studies on recombinant Uev1A show that it localizes to the nucleus, excluding the nucleolar regions . Uev1A functions with TRAF6, a RING domain protein, to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 of ubiquitin . The gene encoding Uev1A maps to human chromosome 20q13.2 .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19
Swiss Prot
Q13404
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human UBE2V1.
Conjugation
Unconjugated
Related Pathways
Ubiquitin Proteasome, Toll-like Receptor signaling
Applications
WB
Dilution
WB 1:500 - 1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 16 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
UBE2V1 polyclonal antibody detects endogenous levels of UBE2V1 protein.
Applications Notes
WesternBlot (WB) analysis of UBE2V1 polyclonal antibody
Host or Source
Rabbit

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