TTC3 polyclonal antibody

• Background:

  E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  DCRR1; RNF105; TPRDIII

• Swiss Prot:

  P53804

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human TTC3

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB 1:500 - 1:2000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  280kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  TTC3 polyclonal antibody detects endogenous levels of TTC3 protein.

• Applications Notes:

  Western blot analysis of extracts of various cell lines, using TTC3 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4