SUCLA2 polyclonal antibody

• Background :

  SUCLA2 (succinate-CoA ligase, ADP-forming, beta subunit), also known as A-BETA, SCS-betaA or renal carcinoma antigen NY-REN-39, is a 463 amino acid mitochondrial matrix enzyme that belongs to the succinate/malate CoA ligase beta subunit family. Widely expressed, SUCLA2 dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. Defects in SUCLA2 may be involved in a group of autosomal recessive disorders known as Mitochondrial DNA depletion syndromes (MDSs) that are characterized by a decrease in mitochondrial DNA copy numbers in affected tissues.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Renal carcinoma antigen NY-REN-39; SCS-betaA; SCS-βA; SCSβA

• Swiss Prot :

  Q9P2R7

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant protein of human SUCLA2.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB 1:500 - 1:1000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 50 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  SUCLA2 polyclonal antibody detects endogenous levels of SUCLA2 protein.

• Applications Notes :

  Western blot analysis of extracts of various cells, using SUCLA2 antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4