RASGRP3 polyclonal antibody

• Background:

  Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  GRP3

• Swiss Prot:

  Q8IV61

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein of human RASGRP3.

• Conjugation:

  Unconjugated

• Applications:

  WB IF

• Dilution:

  WB: 1:500~1:2000 IF: 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 78 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  RASGRP3 polyclonal antibody detects endogenous levels of RASGRP3 protein.

• Applications Notes:

  Western blot analysis of extracts of various cells, using RASGRP3 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4