RASGRP3 polyclonal antibody

• Background :

  Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000

• CAS Number :

  9007-83-4

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  GRP3

• Swiss Prot :

  Q8IV61

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant protein of human RASGRP3.

• Conjugation :

  Unconjugated

• Applications :

  WB IF

• Dilution :

  WB: 1:500~1:2000 IF: 1:50~1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 78 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  RASGRP3 polyclonal antibody detects endogenous levels of RASGRP3 protein.

• Applications Notes :

  Western blot analysis of extracts of various cells, using RASGRP3 antibody.

• Host or Source :

  Rabbit