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RAPGEF3 polyclonal antibody

CAT: 0384-BS6936-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS6936-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
3',5' cyclic adenosine monophosphate (cAMP) -regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; CGEF1; EPAC; EPAC1
Swiss Prot
O95398
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human RAPGEF3.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB 1:500 - 1:2000 IF 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 99 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
RAPGEF3 polyclonal antibody detects endogenous levels of RAPGEF3 protein.
Applications Notes
Western blot (WB) analysis of RAPGEF3 polyclonal antibody
Host or Source
Rabbit

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