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NEIL3 polyclonal antibody

CAT: 0384-BS61905-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61905-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NEIL1, NEIL2 and NEIL3, also known as endonuclease VIII-like 1, 2 and 3 or DNA- (apurinic or apyrimidinic site) lyase NEIL 1, 2 and 3, are nuclear proteins involved in the repair of DNA damaged by oxidation. The NEIL proteins belong to the FPG family. They act as DNA glycosylases that can recognize and remove damaged bases, leaving an abasic site. NEIL3, however, lacks the proline residue at the N-terminus which acts as the active site residue found in NEIL1 and NEIL2. Thus, reports of NEIL3 DNA glycosylase activity are contradictory. NEIL3 localizes to the nucleus and only demonstrates expression in thymus and testis tissues. The deduced 605 amino acid NEIL3 protein contains one FPG-type zinc finger and one RanBP2-type zinc finger.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK; PTK2; FAK; FAK1
Swiss Prot
Q8TAT5
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human PTK2 around the phosphorylation site of Serine 843
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 67 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NEIL3 polyclonal antibody detects endogenous levels of NEIL3 protein.
Applications Notes
Western blot (WB) analysis of NEIL3 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:H1792 whole cell lysate (40ug) Lane3:The Thymus tissue lysate of Rat (40ug) Lane4:The Testis tissue lysate of Mouse (40ug)
Host or Source
Rabbit

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