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Caspase-4 polyclonal antibody

CAT: 0384-BS61766-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61766-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspase-4 (TX/ICH-2/ICErelII) is a member of the caspase family of proteases that play a key role in the execution of apoptosis and activation of inflammatory cytokines. Expression of caspase-4 has been observed in most tissues except brain, with highest levels in placenta, lung, spleen, and peripheral blood lymphocytes (PBL) . Caspase-4 was originally found to contribute to Fas-mediated apoptosis. Several caspases (including caspase-4, caspase-5, and mouse caspase-11 and -12) are most closely related to caspase-1 and are capable of inducing apoptosis when over-expressed but are better characterized in the proteolytic activation of inflammatory cytokines. Caspase-4 associates with TRAF6 and is involved in the LPS inducible production of inflammatory cytokines IL-8 and MIP1 in THP-1 cells. While caspase-4 and mouse caspase-12 localize to the endoplasmic reticulum (ER) and may be activated by drugs that induce ER-stress, at least one study suggests that caspase-4 and caspase-12 are not essential for the ER-stress induced apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Caspase4; Caspase 4; CASP-4; ICE and Ced-3 homolog 2; ICH-2; ICE (rel) -II; Mih1; Protease TX; Caspase-4 subunit 1; Caspase-4 subunit 2; CASP4; ICH2; Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY; Caspase-5 subunit p20; Caspase-5 subunit p10; CASP5; ICH3
Swiss Prot
P49662/P51878
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human Caspase-4.
Conjugation
Unconjugated
Related Pathways
Inflammasonme Signaling, Necrotic Cell Death
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Caspase-4 polyclonal antibody detects endogenous levels of Caspase-4 protein.
Applications Notes
Western blot (WB) analysis of Caspase-4 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:U-87MG whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (10ug) Lane5:PC12 whole cell lysate (40ug)
Host or Source
Rabbit

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