TRIM68 polyclonal antibody

The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM68 (tripartite motif-containing protein 68), also known as RNF137 (RING finger protein 137) or SS56, is a 485 amino acid protein that localizes to the perinuclear region of the cytoplasm. Expressed in a variety of tissues with higher expression in prostate, spleen and fetal liver, TRIM68 associates with androgen receptor (AR) and, via this interaction, enhances the transcriptional activity of AR. TRIM68 is found in various cancers, including prostate cancer cells, and is thought to be a therapeutic target for the detection and treatment of prostate cancer. Additionally, TRIM68 is a target of the autoimmune response exhibited in systemic lupus erythematosus (SLE), primary Sjoegren syndrome and HIV-1 infection.

9007-83-4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68; TRIM68; GC109; RNF137; SS56

Q6AZZ1

Human, Mouse, Rat

Synthetic peptide, corresponding to amino acids 120-170 of Human TRIM68.

Unconjugated

WB

WB: 1:500~1:1000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Unmodification

~ 68 kDa

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.

TRIM68 polyclonal antibody detects endogenous levels of TRIM68 protein.

Western blot (WB) analysis of TRIM68 polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug)