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CD6 polyclonal antibody

CAT: 0384-BS61731-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61731-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD6 is a type I transmembrane glycoprotein that is present on mature thymocytes, peripheral T cells and a subset of B cells. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T-cell activation and the size difference between the CD6 forms is due in part to differences in phosphorylation state. CD6 protein contains a 24-amino acid signal sequence, 3 extracellular “scavenger receptor cysteine-rich” (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. CD6 shows significant homology to CD5. CD6, which is also found in brain and B cell chronic lymphocytic leukemias, plays an important role in interactions of thymocytes with thymic epithelial cells. CD6 molecules can physically associate with the TCR/ CD3 complex.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
T-cell differentiation antigen CD6; T12; TP120; CD6; Soluble CD6; CD6
Swiss Prot
P30203
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human CD6.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 71 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD6 polyclonal antibody detects endogenous levels of CD6 protein.
Applications Notes
Western blot (WB) analysis of CD6 polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (40ug)
Host or Source
Rabbit

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