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POLR3B polyclonal antibody

CAT: 0384-BS61708-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61708-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RNA polymerase II (Pol II) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA. POLR3B (polymerase (RNA) III (DNA directed) polypeptide B), also known as C128 or RPC2, is a 1,133 amino acid protein that localizes to the nucleus and belongs to the RNA polymerase β chain family. Existing as the second largest component of the multi-protein RNA polymerase III (Pol III) complex, POLR3B functions as a DNA-dependent RNA polymerase that specifically catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. The gene encoding POLR3B maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA-directed RNA polymerase III subunit RPC2; RNA polymerase III subunit C2; C128; DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit B; POLR3B
Swiss Prot
Q9NW08
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 330-380 of Human POLR3B.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 127 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
POLR3B polyclonal antibody detects endogenous levels of POLR3B protein.
Applications Notes
Western blot (WB) analysis of POLR3B polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate (20ug) Lane2:H9C2 whole cell lysate (20ug) Lane3:U-87MG whole cell lysate (40ug) Lane4:HCT116 whole cell lysate (40ug) Lane5:MCF-7 whole cell lysate (40ug)
Host or Source
Rabbit

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