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PEA15 polyclonal antibody

CAT: 0384-BS61435-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61435-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PEA-15 (Phosphoprotein Enriched in Astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 colocalizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, Phosphoprotein Enriched in Diabetes, for its elevated expression in type 2 diabetic patients.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED; PEA15
Swiss Prot
Q15121
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 85-130 of Human PEA15.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 15 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PEA15 polyclonal antibody detects endogenous levels of PEA15 protein.
Applications Notes
Western blot (WB) analysis of PEA15 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate (30ug) Lane2:H9C2 whole cell lysate (30ug) Lane3:RAW264.7 whole cell lysate (30ug) Lane4:HEK293T whole cell lysate (30ug)
Host or Source
Rabbit

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