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STEAP2 polyclonal antibody

CAT: 0384-BS61401-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS61401-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STEAP2 (six transmembrane epithelial antigen of the prostate 2), also known as STMP, IPCA1, PUMPCn, STAMP1 or PCANAP1, is a 490 amino acid multi-pass membrane protein that localizes to the cell membrane and the endosomal membrane, as well as to the Golgi and to vesicular tubular structures in the cytosol. Highly expressed in prostate and present at lower levels in kidney, heart, ovary, brain and pancreas, STEAP2 contains one ferric oxidoreductase domain and, using FAD as a cofactor, functions as a metalloreductase that is able to reduce both Cu (2+) and Fe (3+) to Cu (1+) and Fe (2+), respectively, thereby playing a role in iron and copper metabolism. Overexpression of STEAP2 is associated with the progression of prostate cancer, suggesting a role for STEAP2 in tumorigenesis. Multiple isoforms of STEAP2 exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STEAP2; PCANAP1, STAMP1; UNQ6507/PRO23203
Swiss Prot
Q8NFT2
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 440-485 of Human STEAP2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 56 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
STEAP2 polyclonal antibody detects endogenous levels of STEAP2 protein.
Applications Notes
Western blot (WB) analysis of STEAP2 polyclonal antibody at 1:500 dilution Lane1:HEH293T whole cell lysate (40ug) Lane2:The Spleen tissue lysate of Rat (30ug) Lane3:The Spleen tissue lysate of Mouse (30ug)
Host or Source
Rabbit

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