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TFF2 polyclonal antibody

CAT: 0384-BS61335-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS61335-01Size:50 µL
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Background
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Trefoil factor 2; Spasmolysin; Spasmolytic polypeptide; SP; TFF2; SML1
Swiss Prot
Q03403
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human TFF2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 14 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TFF2 polyclonal antibody detects endogenous levels of TFF2 protein.
Applications Notes
Western blot (WB) analysis of TFF2 polyclonal antibody at 1:500 dilution Lane1:HELA whole cell lysate Lane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate
Host or Source
Rabbit

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