CCR4 polyclonal antibody

• Background:

  C-C or β chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potentchemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. CKR-4 (C-C chemokine receptor type 4), also known as CCR4 or CMKBR4, is a 360 amino acidmulti-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family. Expressed at high levels in peripheral blood leukocytes and thymustissue, CKR-4 functions as a high affinity receptor for C-C type chemokines and is thought to be involved in hippocampal-neuron survival.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CCR4; CMKBR4

• Swiss Prot:

  P51679

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide corresponding to residues in Human CCR4.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:500~1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 41 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CCR4 polyclonal antibody detects endogenous levels of CCR4 protein.

• Applications Notes:

  Western blot (WB) analysis of CCR4 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4