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A2M polyclonal antibody

CAT: 0384-BS60859-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60859-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor thatwas able to “bait” proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to “trap”the proteinase and inhibit its further activity. Subsequently, α-2M has also been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serumis primarily bound to α-2M, which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increasesthe concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved inmediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer’s Disease (AD), which isconsistent with the role of α-2M inmediating the clearance and degradation of Aβ, the major component of β-Amyloid deposits accumulated during AD.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5
Swiss Prot
P01023
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human A2M.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:203
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 185 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
A2M polyclonal antibody detects endogenous levels of A2M protein.
Applications Notes
Western blot (WB) analysis of A2M polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:NIH-3T3 whole cell lysate Lane4:PC12 whole cell lysate
Host or Source
Rabbit

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