CHD2 polyclonal antibody

CAT: 0384-BS60787-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS60787-01Size:50 µL
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Background
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains.CHD proteins alter gene expression by modifying chromatin structure, thereby altering access of the transcriptional machinery to its chromosomal DNA template. Chromodomain helicase DNA binding protein 2, also known as CHD2, is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins) . Consisting of 1,828 amino acids, CHD2 is expressed in the nucleus and contains two chromo domains, a helicase ATP-binding domain and a helicase C-terminal domain.CHD2 is suggested to play a critical role in development, hematopoiesis and tumor suppression. Mutations in the gene encoding CHD2 may be the cause of glomerulopathy, proteinuria and significantly impaired kidney function.CHD2 exists as two alternatively spliced isoforms.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2; CHD2
Swiss Prot
O14647
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human CHD2.
Conjugation
Unconjugated
Related Pathways
ATP-Dependent Chromatin Remodeling Complexes
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 211 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CHD2 polyclonal antibody detects endogenous levels of CHD2 protein.
Applications Notes
Western blot (WB) analysis of CHD2 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:A549 whole cell lysate
Host or Source
Rabbit

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