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ADAMTS18 polyclonal antibody

CAT: 0384-BS60769-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60769-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin 1 (TSP 1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-18 is a secreted protein that is also expressed in adult brain, endothelium, prostate and submaxillary gland. ADAMTS-18 has two known splice variants and it is structurally most similar to ADAMTS-16. ADAMTS-18 is downregulated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS-18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18; ADAMTS18
Swiss Prot
Q8TE60
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human ADAMTS18
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 135 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADAMTS18 polyclonal antibody detects endogenous levels of ADAMTS18 protein.
Applications Notes
Western blot (WB) analysis of ADAMTS18 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit

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