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EYA1/4 polyclonal antibody

CAT: 0384-BS60698-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60698-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A gene on chromosome 8q13.3 encodes EYA1 (eyes absent), a protein with 16 exons. EYA1 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serine-threonin) -rich amino terminal is highly divergent. EYA is expressed in flexor tendons and the developing central nervous system, kidney, eye and ear. EYA1 acts a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA1 plays a critical role in the development of the inner ear and kidney. EYA is involved in early inductive signaling, acting upstream of GDNF. EYA1 has been implicated in the autosomal dominant disorders branchio-oto-renal (BOR) syndrome and branhio-oto (BO) syndrome.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Eyes absent homolog 1; EYA1; Eyes absent homolog 4; EYA4
Swiss Prot
Q99502/O95677
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human EYA1/4
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
EYA1/4 polyclonal antibody detects endogenous levels of EYA1/4 protein.
Applications Notes
Western blot (WB) analysis of EYA1/4 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:H9C2 whole cell lysate
Host or Source
Rabbit

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